Ongoing studies are examining the role of triple therapy in less severe symptomatic patients with COPD and asthma–COPD overlap.Ĭurrent recommendations are that the pharmacological treatment of COPD should take a “personalized” approach, based around the use of either single therapy or a combination of medications with different or complementary mechanisms of action. The evidence suggests that triple therapy is the most effective treatment in moderate/severe symptomatic patients with COPD at risk of exacerbations, with marginal if any risk of side effects including pneumonia. Furthermore, triple therapy showed a promising signal in terms of improved survival. ![]() ![]() Overall, compared to LAMA, ICS/LABA, or LAMA/LABA, triple therapy decreased the risk of exacerbations and improved lung function and health status, with a favorable benefit-to-harm ratio. Of the five main fixed triple studies completed so far, three evaluated the efficacy and safety of an extrafine formulation of beclometasone dipropionate, formoterol fumarate, and glycopyrronium the other two studies evaluated fluticasone furoate, vilanterol, and umeclidinium. This review presents the clinical evidence that led to the approval of these triple therapies, discusses the role of ICS in patients with COPD, and presents data on the relative efficacy of “fixed triple” (ICS/LAMA/LABA) therapy vs LAMA, ICS/LABA, and LAMA/LABA combinations, and summarizes studies in which ICS/LABAs were combined with LAMAs to form “open triple” combinations. ![]() Recently, two “fixed triple” single-inhaler combinations of an inhaled corticosteroid (ICS), a long-acting β 2-agonist (LABA), and a long-acting muscarinic antagonist (LAMA) have become available for patients with COPD.
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![]() AMCO’s recommendation would be to add LiveTalk alarm monitoring to it - giving you the best alarm monitoring on the market. If you don’t want to replace your whole alarm system, one option to upgrade your Accenta alarm system is to add alarm monitoring to it. Upgrading your Accenta alarm to have smart functionality using the Texecom Premier Elite alarm will give you the best and most future-proof alarm system, meaning you won't have to upgrade your alarm for a good 20+ years - because of its modular set-up. The Premier is one of the most advanced systems on the market, and has the flexibility of being both wired and wireless and also being modular - meaning that you can easily upgrade in the future - for example adding ‘smartphone app’ functionality. Accenta smart alarm upgradeĪs the Accenta alarm is now getting quite old, the best option is to completely replace the alarm panel (the main brain) and also the remote keypads with a modern system that includes Smart alarm functionality.Īs the Accenta is a wired alarm system this is relatively easy to do - as most new wired alarm systems are compatible / easily swapped out.ĪMCO would recommend replacing the Accenta with the Texecom Premier Elite alarm system. if you remove the keypad yourself, the system will go off and without the engineer code you won't be able to turn the alarm off - as you'll have triggered a tamper alarm. If your Accenta keypad is faulty, or is looking old / scuffed, you can easily replace this. The same goes for standard door contacts and vibration sensors. If you needed Accenta PIR / movement sensors fixing / replacing, AMCO could easily replace these with our standard Texecom PIR sensors. ![]() Need help upgrading your old Accenta system, speak to one of the AMCO team via phone - 0800 13 03 999 - or email alarm sensors Accenta alarm tamper fault: tamper faults on the Accenta are usually to do with a tamper fault on the keypad, main alarm or on a sensor (e.g. Accenta red power light flashing: this is usually a power or battery issue Accenta keypad not working: this usually requires replacing an Accenta keypad Accenta alarm false alarming: this is usually something to do with a faulty sensor (e.g. Accenta alarm keeps beeping: this is usually something to do with an old battery or faulty zone Because the Accenta is a wired alarm system, the good news is that it's easy to replace the core alarm panel with ANY wired alarm system, as wired alarms are generally compatible with each other.Ĭommon faults with Accenta alarms that have ben fixed include: So the option you have is to either fix your existing system, or to change / upgrade your alarm. The good news is that it's relatively easy to fix an Accenta alarm panel - as Honeywell still manufacture the sytem. Both the Accenta and Optima use the same base technology, the main difference being that the Accenta includes a remote keypad. The Accenta is a 100% wired alarm, and has a smaller sister alarm called the Optima. The Accenta is an alarm system first developed by technology company Honeywell in the early 2000's, as a robust all-round alarm system. Upgrade / fix / replace old Accenta alarm Select one or both of the following check boxes:Īllow the signer to add comments in the Sign dialog box Allow the signer to type a purpose for signing. Instructions to the signer Add instructions for the signer, such as "Before signing the document, verify that the content is correct." Suggested signer's e-mail address The signer's e-mail address, if needed. Suggested signer's title The signer's title, if any. In the Signature Setup dialog box, type information that will appear beneath the signature line: On the Insert tab, in the Text group, click the Signature Line list, and then click Microsoft Office Signature Line. In the document or worksheet, place your pointer where you want to create a signature line. Important: A digitally-signed document becomes read-only to prevent modifications. When the signer adds a visible representation of a signature to the document, a digital signature is added at the same time to authenticate the signer's identity. Write a signature by using the inking feature of a touch-screen PC Select a picture of an inked signature, or When an electronic copy of the file is sent to the intended signer, this person sees the signature line and a notification that their signature is requested. When a signature line is inserted into a Microsoft 365 file, the author can specify information about the intended signer, and instructions for the signer. Top of Page Signature lines in Word and ExcelĪ signature line resembles a typical signature placeholder that might appear in a printed document. The certificate associated with the digital signature is issued to the signing publisher by a reputable certificate authority (CA). Important: Signed documents, which have a valid time stamp, are considered to have valid signatures, regardless of the age, or revocation status, of the signing certificate. A certificate is usually valid for a year, after which, the signer must renew, or get a new, a signing certificate to establish identity. Certificates are issued by a certification authority, and like a driver’s license, can be revoked. When you send a digitally-signed macro or document, you also send your certificate and public key. Signing certificate To create a digital signature, you have to have a signing certificate, which proves identity. Signing certificate and certificate authority A signature confirms that the information originated from the signer and has not been altered. Remove invisible digital signatures from Word, Excel, or PowerPointĪ digital signature is an electronic, encrypted, stamp of authentication on digital information such as e-mail messages, macros, or electronic documents. Invisible digital signatures in Word, Excel, or PowerPointĪdd invisible digital signatures in Word, Excel, or PowerPoint Remove digital signatures from Word or Excel This article explains digital signatures (also known as digital ID), what they can be used for, and how you can use digital signatures in the following Microsoft 365 applications: Word, Excel, and PowerPoint. ![]() ![]() Early episodes trace the origins of American Chinese food and Big Pizza, featuring anecdotes about portable pizza warmers and the jump in the popularity of Chinese restaurants after President Richard Nixon visited the country in the 1970s. The show covers both the pleasure of eating and the exploitation of gig workers by big tech companies. ![]() Once made up almost exclusively of pizza and General Tso’s chicken ordered over a landline, the landscape is now technologically sophisticated and morally complex. The new season of Dish City is a comprehensive study of the ballooning pandemic food-delivery marketplace. It’s also a call to arms for people with disabilities a story about power, sexism, and isolation and a reflection on who has the right to make bad decisions. Fueled by their Britney fandom and by Barker’s research chops, Toxic takes a look at Spears’s first and second marriages, her infamous 2007 public persona, and the absurdity of the media’s reaction to her shaved head. The women eventually gained a massive following. Tips explaining her silence came in and checked out: She’d been forced into a mental-health facility. But when Spears stopped posting, they started researching and showing up to her hearings. Comedians Tess Barker and Babs Gray’s first podcast, Britney’s Gram, analyzed the pop star’s Instagram feed. Instead, awareness of Spears’s recent triumph gives a hopeful sheen to the work by the two women who popularized the #FreeBritney movement. Knowing that Toxic: The Britney Spears Story has a happy ending isn’t a spoiler. (And a special shoutout to Dan Taberski, the first host to ever earn two of our top-five spots.) They pushed the form, helped us metabolize the world around us (or escape from it), and embodied the spirit of 2021. The 50 shows on this list outdid their competitors in both ambition and success. Producers zeroed in on terrorism-both domestic and abroad-searching for patterns and reaching for hindsight. Others drew parallels between the pandemic and the AIDS crisis or the aftermath of 9/11. ![]() Some shows were hornier than ever before others sharply connected sex to gendered power dynamics. In other series, our houses themselves-and the attendant challenges around gentrification and homelessness- were the story. Memoirs also shone, allowing homebound producers to shout into the void. As the pandemic wore on and limited field reporting, archival tape became central to narratives. This year, makers played with structure in fresh ways, flirting with form and cadence. As always, we’ve also recused ourselves from selecting The Atlantic’s podcasts. True-crime shows and in-depth looks at government snafus remain available in droves, but we sought series that transcended their genre conventions. We’ve decided to eliminate anything that sounds like it’s always sounded, too. The requisites for inclusion on our list have evolved over time, and now we only consider new shows or shows that have a new focus. Ours is, as far as we know, the longest-running of the robust roundups, and we’ve been reviewing the medium longer than virtually any other critic in the space. This is our seventh list commemorating the year’s best podcasts, and deciding what makes the cut has only gotten harder each time. From there, each and every slot is labored over and debated. (Of course, with more than a million podcasts in existence, our extensive listening still makes only a tiny dent.) To track our impressions, we make a spreadsheet with legends, drop-down menus, color codes, formulas, and notes on the thousands of podcasts that we’ve discovered over the past decade. We seek shows anywhere we can find them-sometimes hearing about them directly from producers, other times from a friend of a friend’s mother’s uncle, or sometimes through our own secret methods of rooting out gems. Editor’s Note: Find all of The Atlantic’s “Best of 2021” coverage here. On future versions of the app more free features will be added so stay tuned. Please notice that the android OS do not allow the alarm clock to turn off while your phone is off. If you love the have please review it on the play store and write why you think the app is so good. If you think that my best is not good enough please contact me via email: ,com and leave me a feedback (it’s better via mail because it’s a two way communication). I do my best to make the alarm clock as simple and effective as possible. The good & simple alarm clock includes a simple and cool interface and is great for all the heavy sleepers, kids, and everyone who wants to set an alarm as easy and quick as possible. * Cool and simple user interface so everyone can use it easily. * Effective tips about how to sleep well, how to wake up energized, how to create the best morning routine and the best night routine. * Quick Alarm - Just move your finger on the screen to set the time you want the app to wake you up. * Snooze including some advance settings. * Vibrate including some advance settings. * Works also on android 6 (marshmallow) unlike other alarm clocks. * Gradual fading in of the alarm music to wake up gently. * Loud sound - The default music volume is the maximum volume for the phone. * Use your own personal tone– A music file from the device or a ringtone from the android OS. * Set alarms in advance for the entire week. * Set unlimited number of alarms (great for heavy sleepers who wants few alerts in a row to make sure they wake up). You can also choose the difficulty level of the math question. * A math question to dismiss in case you use to dismiss while you are sleeping. The current version of the good & simple alarm clock includes some basic features: ![]()
![]() We’re for all generations and levels of makeup expertise, from the makeup-savvy individual who is always on the hunt for new trends to the minimalist. The brand's mission? "Offering innovative, accessible, and effortless cosmetics for all by providing technologically advanced formulas with on-trend expertise and New York City edge."įeinstein went on to emphasize the importance of empowering the Maybelline community, "At Maybelline, we use our products to help make everyone, everywhere feel ready to take on their world. A century later, Maybelline New York became the number one cosmetic brand globally, available in over 120 countries. In the 1950s, the first makeup commercials people watched on TV were Maybelline’s."įrom humble beginnings in 1915 to now, it's important to understand the impact and magnitude that Maybelline New York has had on the cosmetics industry. While there are many countless groundbreaking "firsts" from Maybelline New York, Feinstein notes one of the most memorable moments from the brand hails from the 1940s, "How-to ads featuring stars such as Hedy Lemarr showed women different ways to wear makeup in which, at that time, they’d only seen at the theater. Feinstein notes, "This iconic mascara was an instant hit – and is still one of the brand’s best-selling products to this day, selling one Great Lash tube every 5 seconds!" ![]() The most iconic makeup product of all was Maybelline Great Lash Mascara, the green and pink tube inspired by fashion designer Lily Pulitzer. Fast forward to 1971, and mascara became a permanent fixture on everyone's vanity. While the first mascara was created in 1915, it has certainly come a long way since then, and we have Thomas Lyle Williams and Maybelline to thank for it. Other Brands You'll Love: Cover Girl, Physician's Formula, NYX Cosmetics ![]() Thomas then went on to invent the very first mascara and came up with the name Maybelline by combining his sister's name and the key ingredient that helped create it: Vaseline. Most Popular Products: Great Lash Mascara, Instant Age Rewind Concealer, Sky High Mascara, Matte Ink Liquid Lipstickįun Fact: Thomas Lyle Williams wanted to create a product to embellish eyelashes, and would watch his sister, Mabel, mix vaseline and coal dust together to enhance and open up her eyes. India/South Asia: ( HBO Hits (India) | HBO Defined) | HBO en Español | HBO GO (Latin America) | Red by HBO 4Īvenue 5 | 100 Foot Wave | Barry | A Black Lady Sketch Show | Back on the Record with Bob Costas | Chillin Island | Curb Your Enthusiasm | Euphoria | Game Theory with Bomani Jones | The Gilded Age | Hard Knocks | His Dark Materials | House of the Dragon | How To with John Wilson | Industry | The Last of Us | Last Week Tonight with John Oliver | Los Espookys | My Brilliant Friend | The Nevers | Painting with John | Pause with Sam Jay | Perry Mason | Random Acts of Flyness | Real Sports with Bryant Gumbel | Real Time with Bill Maher | The Rehearsal | The Righteous Gemstones | The Shop | Somebody Somewhere | Succession | The Vow | We're Here | The White Lotus | Winning Time: The Rise of the Lakers DynastyĪgents of Chaos | All the Rivers Run | Allen v. Latin America: HBO Pack | HBO | HBO 2 | Family | Signature | Mundi | Xtreme | Pop | HBO +ĭivested: BET 1 | Comedy Central 2 | TriStar Pictures 3ĭefunct: Festival | HBO (application) | HBO Home Entertainment | HBO Max | HBO Nordic | HBO España | HBO Portugal | Take 2 Southeast Asia: Asia ( Hits | Signature | Family)Įurope: HBO Central Europe | HBO ( Croatia | Czech Republic and Slovakia | Hungary | Poland | Romania) | HBO 2 ( Czech Republic and Slovakia | Hungary | Poland | Romania) | HBO 3 ( Poland | Romania) | HBO GO HBO ( On Demand) | HBO 2 | HBO Comedy | HBO Family | HBO Latino | HBO Signature | HBO Zone This was the last month of my using.HBO Films | HBO Documentary Films | HBO Entertainment | HBO Enterprises | HBO Kids | HBO Sports How many fucking times are you going to do this to yourself?" The end was soon to come. It could make me forget all my troubles If I could only sleep a little longer maybe I can make this feeling real. He wanted to walk hand in hand with me while I limped and drained and grimaced in pain. The insanity of our routine did not diminish our affection. ![]() The blood and the drugs were all part of the relationship. And he would sit with me for hours as I tried to get a hit, switching from syringe to new syringe. I had just left Ben when we met so I was not looking for a relationship. He never passed judgement and he never asked me to do things I wasn't willing to do for drugs. He had been raised by junkies so he took care of me in a way I didn't quite comprehend at the time. We were slowly draining the life from each other.ĭaniel and I were the oddest of couples, yet heroin made everything fall into place. I prayed that he would get better yet I was killing him at the same time. I wished I could just curl up in the bed next to him and watch him sleep. They gave him 10mg of methadone and I gave him three grams of heroin. I kissed him deeply and transferred the balloons into his mouth. His eyes and skin were yellow when I helped him check in there. The only way I could get him to go to the hospital with a raging hepatitis infection was the promise of drugs. He is one to tell me about being careful. I let him fix before I did mine and he is just now feeling it. He is slowly sinking forward at the side of the bed. He said this he brushed the hair away from his nodding face. You are going to lose that leg if you aren't careful". I was living outdoors, I was sick, and I knew this might happen. That day, I did not have the luxury of searching for a vein for two hours. I muscled dope through my pants leg that I mixed with dirty water. A place inside when I could let this wound drain into a loose bandage. When I got the hard core of the infection out, I would clean out the area. I had taken a new syringe and stuck in the middle of the infected area. I was quite the amateur doctor, at least in my mind. The clinic would slice me open and send me on my way with some sterile water and gauze to pack my wounds. It wasn't getting all that red or hard but it hurt to walk. I needed to lance this abscess to get the pressure off. For now, I needed a place where I could take off my pants. ![]() ![]() Soon, we will have to do the whole thing all over again. We had hustled all day to get the $35 we needed to stay here tonight plus money for dope. I was laying on the bed of our hotel room. ![]() That question rang in my mind for a month to come. How many fucking times are you going to do this to yourself?" "Hand me the alcohol wipes" I reach over the bed " this is finally starting to drain" ![]() After a few unsuccessful attempts at drawing him away, Mion leaves and Shion, Jirou and Miyo reveal that mysterious deaths and disappearances have occurred during the festival over the last few years. It would defeat the point of the title if we could see her, right spykor 2 yr. This gets Keiichi’s attention, but just as he inquires as to what Shion means, Mion tries to pull him away from the conversation. The many faces of Shion (episode 23) 247 11 comments Add a Comment 8andahalfby11 2 yr. The five of them are soon interrupted by Ooishi when Shion mentions that she hopes that the festivities occur without another incident. He runs into Shion and Mion and Jirou and Miyo, as well. The day before the Watanagashi Festival, Keiichi is helping the townsfolk with their preparations. ![]() Inside, he runs into the real Mion and finally puts it all together. Still thinking that she’s just Mion in disguise, Keiichi is confused but agrees to do so. Shion is predictably paranoid about Rika’s intentions and overpowers her, injecting Rika instead. Rika knows that Shion is suffering from high levels of Hinamizawa Syndrome and wants to use C-120 to reduce the symptoms. Shion asks him to buy her the same doll he’d given Mion that day. Irie for the purpose of subduing level 4 and 5 stages of Hinamizawa Syndrome. After Keiichi comes to, both he and Shion walk around town, eventually passing by the game store he and his previously held their tournament at. Keiichi notices a customer harassing Shion and intervenes, but is knocked out cold in doing so. The next day, Keiichi is called back to Angel Mort by Shion to taste test some sweets. ![]() You'll come across puzzles you need to solve just because they're there, not because logic dictates solving it will further your journey. Suffice to say that I "solved" some of the puzzles in Syberia by randomly dragging items from my inventory to whatever hot spot I was standing by. I really don't want to get into specifics, as puzzle fanatics may sneak into the IGN offices and murder me for giving away solutions. In true yin/yang fashion, Syberia II's good puzzles are balanced by some truly gnarly ones. It closely resembles something you would do in real life to get yourself out of a similar bind, given similar circumstances. Not to say the puzzle feels overly simplistic it just doesn't require abstract thought to solve. The solution is so blatantly logical it's obscene. For example, early on, Kate needs to wake up a pilot who has fainted after his plane crashes on a snowy mountaintop. Even with some frustrations, the game does a pretty good job overall of integrating puzzles into the game world. The puzzles in Syberia II are a mixed bag of anything from flawlessly logical brain teasers to completely illogical brain roasters. ![]() When not rummaging through a hundred billion pixels to activate the aforementioned hot spots, chances are you'll be out solving puzzles. It is way too easy to completely miss an entire section of a restaurant, bar or what have you just because you don't hold title as the world's best hot spot hunter. Which brings up problem number one: unless you have super-vision, you'll either need cornea implants or your glasses cleaned and tweaked to find some of the more reclusive hot spots in this game. Usually, this means mousing over characters to initiate a conversation or scrolling over an item to pick it up. As in most games of this type, a bulk of the adventure will have you moving your cursor around the screen in search of hot spots. Now though, you only make a few phone calls that actually matter story-wise, making the phone feel more like a novelty than anything else. I really didn't mind the heavy cell use in the first game, as it sometimes provided bits of needed info on the story. She ends up hanging up on most of the calls she gets. The cell phone has taken a backseat in Syberia II, as Kate Walker has pretty much severed all connections with her former self. Fans of the original will remember getting tons of phone calls from Kate Walker's mother, boyfriend and boss. ![]() You control Kate Walker through a very simple interface made up of an inventory screen, a document screen, and of course, a slot for Kate's cell phone. Most previews of Syberia II mention the first few hours spent in the dreary town of Romansbourg, so I'll just skip past all that. ![]() Kate Walker forsakes family and career to head off into the frozen north in search of the old man's dream, even if she's still not too sure about it herself. She's now resolved to help Hans Voralberg reach the mythical island of Syberia. She disregards her boss's plea to have her return home to New York after she left for France on a business trip weeks earlier. The opening movie in Syberia II reveals Kate Walker letting go of her roots. It's ok if you don't know what I'm talking about, Syberia II graciously provides a bite-sized prologue for the Syberia virgins of the world through an optional cinematic. The trio soon boards a whimsical wind-up train and shoot into the frozen unknown in search of Syberia. Kate Walker meets and joins Oscar, a wimpy yet loyal automaton built by Hans, in a bid to realize the crazed dreams of the frail old man. The old man seemed deliriously obsessed with finding Syberia, a sacred island where Mammoths still freely roam. When gamers last saw Kate Walker, she had found the elusive Hans Voralberg, an aging toymaker who built advanced machines and automatons. Perhaps the biggest puzzling game phenomenon since Sudoku in the early 2000s, Wordle’s user base has skyrocketed from only 90 players a day when the game was first released to over two million daily players today. ![]() Their family’s interest inspired Wardle to release the game to a global audience in November of 2021, where it has quickly become an internet favorite. ![]() The two played the game amongst themselves for many months before they shared it in a family WhatsApp group, where it quickly became popular. He created the game as a way to keep himself sharp during quarantine, and as a gift for his partner, Palak Shah, who loves word games. Wordle was first envisioned in 2020 by Josh Wardle, a Brooklyn-based software engineer. As you advance in the game, our suggestions will become more targeted.
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